Offering a restaurant and baggage storage, the 2-star Meddusa Hotel Istanbul lies in the Old City Sultanahmet district, a mere 600 metres from Topkapi Palace harem and approximately 600 metres from Istanbul Museum of the History of Science and Technology in Islam. A cash machine and a currency exchange are also available at this budget hotel.

Situated in the old part of Istanbul, the property is a few minutes' drive from Vezneciler-Istanbul Universitesi underground station. The Meddusa is within 10 minutes' walk of Big Tours Istanbul bus stop and a few steps from Nuruosmaniye Mosque. Nature lovers will appreciate the proximity to Sea of Marmara, which is a 5-minute ride away. Also, Meddusa Hotel is 18 minutes' stroll from Galata Koprusu Bridge, and Sirkeci train station is located only 10 minutes' walk away. For those travelling from afar, Istanbul Sabiha Gokcen International airport is 47 minutes' drive away.

There are 16 rooms with a place for dining and a mini-kitchen. Some of them offer free wireless internet and a flat-screen TV with satellite channels, along with a coffee maker and a minibar. Also, they feature marble flooring. The private bathrooms have a separate toilet and a shower, along with comforts such as hairdryers and bath sheets. Guests can also enjoy views of the garden. Self-catering facilities in a studio suite include a kitchenette with a coffee maker, a fridge, and kitchenware.

The Meddusa Istanbul serves a buffet breakfast in the morning. For a drink, you can stop by the small lounge bar. The accommodation is close to the café Kahve Dunyasi.